Research Journal of Pharmacy and Technology

Sai Gnaneswari Aluri ¹, Mukthinuthalapati Mathrusri Annapurna ¹

Affiliations
1 Department of Pharmaceutical Analysis, Gandhi Institute of Technology and Management (Deemed to be University), GITAM School of Pharmacy, Visakhapatnam, Andhra pradesh-530045,, IN

Abstract

Etoricoxib is a selective COX-2 inhibitor and used as a non-steroidal anti-inflammatory drug. A new validated stability indicating RP-UFLC method has been developed for the estimation of Etoricoxib in pharmaceutical dosage forms (Tablets). Shimadzu UFLC system (PDA detector) with Agilent C18 column was chosen for the chromatographic study with mobile phase Acetonitrile: water (50: 50) and flow rate 0.8 mL/min (UV detection at 230 nm). Beer-Lambert’s law was obeyed over a concentration range 0.1-100 μg/mL. The linear regression equation was found to be y = 82642x -13032 (R² = 0.9998). The LOD and LOQ was found to be and 0.0291 and 0.0894 μg/mL respectively. Stress degradation studies were performed and the method was validated as per ICH guidelines. The proposed method is simple, precise, accurate and robust and can be applied for the quantification of Etoricoxib formulations.

Keywords

Etoricoxib, RP-UFLC, Stability indicating, Validation, ICH guidelines.

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